The Sf1-related nuclear hormone receptor Hr39 regulates Drosophila female reproductive tract development and function


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The Sf1-related nuclear hormone receptor Hr39 regulates Drosophila female reproductive tract development and function.

The vertebrate nuclear hormone receptor steroidogenic factor 1 (SF1; NR5A1) controls reproductive development and regulates the transcription of steroid-modifying cytochrome P450 genes. We find that the SF1-related Drosophila nuclear hormone receptor HR39 is also essential for sexual development. In Hr39 mutant females, the sperm-storing spermathecae and glandular parovaria are absent or defect...

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NR5A Nuclear Receptor Hr39 Controls Three-Cell Secretory Unit Formation in Drosophila Female Reproductive Glands

BACKGROUND Secretions within the adult female reproductive tract mediate sperm survival, storage, activation, and selection. Drosophila female reproductive gland secretory cells reside within the adult spermathecae and parovaria, but their development remains poorly characterized. RESULTS With cell-lineage tracing, we found that precursor cells downregulate lozenge and divide stereotypically ...

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Mating‐regulates reproductive‐tract neuromodulators in Drosophila

MARIANA F. WOLFNER Department of Molecular Biology and Genetics Cornell University Ithaca, NY 14853 USA E-mail: [email protected] DOI: 10.1002/mrd.22338 Mating regulates the available combinations of neuromodulators in Drosophila reproductivetract regions. This results in a combinatorial “code” of neuromodulators that changes with place and time, and is proposed to coordinate function...

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An evolutionary conserved interaction between the Gcm transcription factor and the SF1 nuclear receptor in the female reproductive system

NR5A1 is essential for the development and for the function of steroid producing glands of the reproductive system. Moreover, its misregulation is associated with endometriosis, which is the first cause of infertility in women. Hr39, the Drosophila ortholog of NR5A1, is expressed and required in the secretory cells of the spermatheca, the female exocrine gland that ensures fertility by secretin...

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Comparative female reproductive tract development and morphology

A brief description of the basic pattern of mammalian organogenesis of the female reproductive tract is presented based on events as they occur in human beings. The emphasis is not on the details of this development, but rather its organization and timing. Tables of comparative development provide a comparison of similar events between man, rat, mouse, and chick.

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عنوان ژورنال: Development

سال: 2008

ISSN: 1477-9129,0950-1991

DOI: 10.1242/dev.015156