The spontaneously diabetic Wistar rat (the ?BB? rat)
نویسندگان
چکیده
منابع مشابه
Islet cell surface antibodies and lymphocyte antibodies in the spontaneously diabetic BB Wistar rat.
Plasma from 14 diabetic and 6 nondiabetic BB Wistar rats along with plasma from 6 non-BB Wistar rats was evaluated for the presence of islet cells surface antibodies (ICSA) and antibodies to spleen lymphocytes by the protein-A radioligand assay. Dispersed Wistar rat islet cells incubated with plasma from diabetic rats bound 4255 +/- 2208 cpm 125I-protein A/5 x 10(4) islet cells (mean +/- SD) co...
متن کاملUltrastructural changes in the gracile nucleus of the spontaneously diabetic BB rat.
The present study describes the structural changes in the gracile nucleus of the spontaneously diabetic BB rat. At 3-7 days post-diabetes, axons, axon terminals and dendrites showed electron-dense degeneration. Degenerating axons were characterized by swollen mitochondria, vacuolation, accumulation of glycogen granules, tubulovesicular elements, neurofilaments and dense lamellar bodies. Degener...
متن کاملPathologic studies of the blood--retinal barrier in the spontaneously diabetic BB rat.
The BB rat spontaneously develops a diabetic state that closely resembles human type I diabetes. The authors studied the pathologic changes of the retina and retinal pigment epithelium of four normal and nine diabetic BB rats using (1) light and electron microscopy with the horseradish peroxidase tracer technique, and (2) trypsin digest preparations of the retinal vessels. They observed a retin...
متن کاملThe BB Wistar Rat as a Diabetic Model for Fracture Healing
The advent of improved glucose control with insulin and oral medications has allowed for the diabetic population to live longer and healthier lives. Unfortunately diabetes remains a worldwide epidemic with multiple health implications. Specifically, its affects upon fracture healing have been well studied and shown to have negative effects on bone mineral density, biomechanical integrity, and f...
متن کاملComplement-fixing islet cell antibodies in the spontaneously diabetic BB rat.
Fourteen rats of the spontaneously diabetic BB line were bled from the retroorbital sinus approximately every 10 days. Sera taken from an early age up to 20 days after the onset of overt diabetes were assayed for complement-fixing antibodies against antigens of the surface of islet cells (CFA). Dispersed islet cells from normal Wistar rats prelabeled with 3H-leucine were used as targets. Target...
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ژورنال
عنوان ژورنال: Diabetologia
سال: 1978
ISSN: 0012-186X,1432-0428
DOI: 10.1007/bf00429781