The targeting of US28 is dependent on GASP-1
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چکیده
منابع مشابه
The targeting of US28 is dependent on GASP-1
Background The human cytomegalovirus (HCMV) encodes the seven transmembrane (7 TM)/G protein-coupled receptor (GPCR) US28. US28 is able to endocytose and signal in a constitutive i.e. ligand-independent manner and is located predominantly in the membranes of intracellular organelles, especially late endosomes/lysosomes and multivesicular bodies (MVBs). It was suggested that the virions of HCMV ...
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Address: 1Institute of Experimental and Clinical Pharmacology, Medical University of Graz, 8010 Graz, Austria , 2Ernest Gallo Clinic and Research Center, University of California San Francisco, CA 94608, USA, 3Leiden/Amsterdam Center for Drug Research (LACDR), Division of Medicinal Chemistry, Faculty of Sciences, VU University Amsterdam, 1081 HV Amsterdam, The Netherlands and 4Department of Der...
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US28 is a chemokine receptor encoded by the human cytomegalovirus (hCMV) and seems to be crucial for viral propagation. It is a constitutively active receptor. For instance it was shown that US28 signals via Gq/PLC and activates the transcription factors nuclear factor κB (NFκB), cyclic AMP response element binding protein (CREB) and nuclear factor of activated T-cells (NFAT). Hence, the recept...
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قاعده مقتضی و مانع در متون فقهی کم و بیش مستند احکام قرار گرفته و مورد مناقشه فقهاء و اصولیین می باشد و مشهور معتقند مقتضی و مانع، قاعده نیست بلکه یکی از مسائل ذیل استصحاب است لذا نگارنده بر آن شد تا پیرامون این قاعده پژوهش جامعی انجام دهد. به عقیده ما مقتضی دارای حیثیت مستقلی است و هر گاه می گوییم مقتضی احراز شد یعنی با ماهیت مستقل خودش محرز گشته و قطعا اقتضاء خود را خواهد داشت مانند نکاح که ...
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ژورنال
عنوان ژورنال: BMC Pharmacology
سال: 2009
ISSN: 1471-2210
DOI: 10.1186/1471-2210-9-s2-a1