Treating Depression and Depression-Like Behavior with Physical Activity: An Immune Perspective

Treating Depression and Depression-Like Behavior with Physical Activity: An Immune Perspective

The increasing burden of major depressive disorder makes the search for an extended understanding of etiology, and for the development of additional treatments highly significant. Biological factors may be useful biomarkers for treatment with physical activity (PA), and neurobiological effects of PA may herald new therapeutic development in the future. This paper provides a thorough and up-to-d...

Depression, Obesity, Eating Behavior, and Physical Activity

Treating depression with cannabinoids

Although a variety of drugs are available for the treatment of depression, therapy is not effective in all cases and finding alternative options is desirable. Results from animal studies, anecdotal experience reported by patients using cannabis and observations from clinical studies where cannabinoids were used in serious diseases suggest an anti-depressive potential of cannabinoid receptor ago...

Treating depression with exercise: The inflammasome inhibition perspective

Patients with chronic inflammation present increased blood levels of circulating cytokines and often are associated with symptoms of depression. The activation of the immune cells microglia in the brain of depressed patients has been associated with a greater prevalence of suicide, indicating a crucial role of neuroinflammation in the neuropathology of depression. In the modern lifestyle, decre...

A pragmatic randomised controlled trial to evaluate the cost-effectiveness of a physical activity intervention as a treatment for depression: the treating depression with physical activity (TREAD) trial.

OBJECTIVE The TREAting Depression with physical activity (TREAD) study investigated the cost-effectiveness of a physical activity intervention, in addition to usual general practitioner care, as a treatment for people with depression. DESIGN An individually randomised, pragmatic, multicentre randomised controlled trial with follow-up at 4, 8 and 12 months. A subset of participants took part i...