Variability of Oxalobacter Formigenes and Oxalate in Stool Samples
نویسندگان
چکیده
منابع مشابه
Anabolic Incorporation of Oxalate by Oxalobacter formigenes.
Cell-free lysates of the strict anaerobe Oxalobacter formigenes contained the following enzymatic activities: oxalyl coenzyme A reductase, glyoxylate carboligase, tartronic semialdehyde reductase, and glycerate kinase. NAD(P)-linked formate dehydrogenase, serine-glyoxylate aminotransferase, and NAD(P) transhydrogenase activities were not detected. These results support the hypothesis that O. fo...
متن کاملOxalobacter formigenes Colonization and Oxalate Dynamics in a Mouse Model.
Animal and human studies have provided compelling evidence that colonization of the intestine with Oxalobacter formigenes reduces urinary oxalate excretion and lowers the risk of forming calcium oxalate kidney stones. The mechanism providing protection appears to be related to the unique ability of O. formigenes to rely on oxalate as a major source of carbon and energy for growth. However, much...
متن کاملProteome Dynamics of the Specialist Oxalate Degrader Oxalobacter formigenes.
Oxalobacter formigenes is a unique intestinal organism that relies on oxalate degradation to meet most of its energy and carbon needs. A lack of colonization is a risk factor for calcium oxalate kidney stone disease. The release of the genome sequence of O. formigenes has provided an opportunity to increase our understanding of the biology of O. formigenes. This study used mass spectrometry bas...
متن کامل[Oxalobacter formigenes--characteristics and role in development of calcium oxalate urolithiasis].
Microorganisms are one of the important factors for urinary calculi formation. While urease-positive bacteria and nanobacteria contribute to stone formation, Oxalobacter formigenes rods play a protective role against the development of urolithiasis. Proteus mirabilis alkaline environment of the urinary tract and cause crystallization mainly of struvite (magnesium ammonium phosphate). However, n...
متن کاملStructure/Function Relationships in OxlT, the Oxalate/Formate Antiporter of Oxalobacter formigenes
We constructed a single cysteine panel encompassing transmembrane helix two (TM2) of OxlT, the oxalate/ formate antiporter of Oxalobacter formigenes. Among the 21 positions targeted, cysteine substitution identified one (phenylalanine 59) as essential to OxlT expression and three (glutamine 56, glutamine 66, and serine 69) as potentially critical to OxlT function. By probing membranes with a bu...
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ژورنال
عنوان ژورنال: Journal of Urology
سال: 2007
ISSN: 0022-5347,1527-3792
DOI: 10.1016/j.juro.2007.06.045