the association between inflammatory markers and obesity-related factors in tehranian adults: tehran lipid and glucose study

objective(s):obesity considered being a low-grade inflammatory disease. the objective of this study was to examine the association between inflammatory markers (im) including c-reactive protein (hs-crp), interleukin-6 (il-6), and homocystein (hcy) and obesity[f1] -related factors (e.g. bmi, waist, hip) in adult participants of tehran lipid and glucose study (tlgs). materials and methods: in this cross-sectional study, 352 individuals (132 men and 220 women), age ≥19 years, were randomly recruited from participants of tlgs population[f2] . the serum levels of hs-crp, il-6, hcy were determined using the enzyme linked immunosorbent assay (elisa) method[f3] . variables were compared by sample t-test. bivariate linear correlation was estimated using pearson’s correlation coefficient. linear regression analysis was applied to investigate the association between ims and anthropometric and biochemical variables. results: the mean age of participants was 46.1±16.1 years. abdominal obesity was present in 199(56.5%) individuals. levels of hs-crp and il-6 increased in the abdominally obese group (1507±3.3 vs. 577.8±4.3 ng/ml p<0.001) (3.6±3.3 vs. 1.9±3.8 pg/ml p< 0.001), and in the same group, the best predictors for hs-crp, il-6 and hcy were waist (wc), waist to height ratio (whtr) and wrist respectively; hip and whtr were the best predictors for hcy and hs-crp in the normal group. a linear augmentation in hs-crp and il-6 levels was observed in association with obesity categorizes. conclusion: this study provides evidence that abdominally obese individuals had higher levels of ims. wrist, waist and whtr were the best predictors for hcy, hs-crp and il-6 respectively in this group.