“silymarin”, a promising pharmacological agent for treatment of diseases

نویسندگان

gholamreza karimi medical toxicology research center, school of pharmacy, mashhad university of medical sciences, mashhad, iran

maryam vahabzadeh department of pharmacodynamy and toxicology, school of pharmacy, mashhad university of medical sciences, mashhad, iran

parisa lari department of pharmacodynamy and toxicology, school of pharmacy, mashhad university of medical sciences, mashhad, iran

marziyeh rashedinia department of pharmacodynamy and toxicology, school of pharmacy, mashhad university of medical sciences, mashhad, iran

چکیده

widespread use of herbal drugs because of their protective effects on different organs toxicity has been shown in many studies. these protective effects have been illustrated in the fields of nephrotoxicity, hepatotoxicity, viral hepatitis, cancer, in vitro fertilization, neurotoxicity, depression, lung diseases, prostate diseases etc. silymarin has cytoprotection activities due to its antioxidant activity and radical scavenging. the possible known mechanisms of action of silymarin protection are blockade and adjustment of cell transporters, p-glycoprotein, estrogenic and nuclear receptors. moreover, silymarin anti-inflammatory effects through reduction of tnf-a, protective effects on erythrocyte lysis and cisplatin-induced acute nephrotoxicity have been indicated in some studies. silymarin has also inhibited apoptosis and follicular development in patients undergoing ivf. basis on such data, silymarin can be served as a novel medication in complementary medicine.

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“Silymarin”, a Promising Pharmacological Agent for Treatment of Diseases

Widespread use of herbal drugs because of their protective effects on different organs toxicity has been shown in many studies. These protective effects have been illustrated in the fields of nephrotoxicity, hepatotoxicity, viral hepatitis, cancer, in vitro fertilization, neurotoxicity, depression, lung diseases, prostate diseases etc. Silymarin has cytoprotection activities due to its antioxid...

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عنوان ژورنال:
iranian journal of basic medical sciences

جلد ۱۴، شماره ۴، صفحات ۳۰۸-۳۱۷

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