vitamin e derivative alpha-tocotrienol failed to show neuroprotective effects after embolic stroke in rats

نویسندگان

mohammad allahtavakoli department of physiology, school of medicine, rafsanjan university of medical sciences, rafsanjan, iran

aliasghar pourshanazari department of physiology, school of medicine, rafsanjan university of medical sciences, rafsanjan, iran

behnam heshmatian department of physiology, school of medicine, west azarbaeejan university of medical sciences, oroomiah, iran

چکیده

objective(s) previous studies have demonstrated that pretreatment with alpha-tocotrienol (a-tct) can reduce ischemic damage in mice following middle cerebral artery (mca) occlusion. it is also reported to decrease stroke- dependent brain tissue damage in 12-lox-deficient mice and spontaneously hypertensive rats. in the present study, the neuroprotective effects of a-tct and rosiglitazone (rgz) at 3 hr after cerebral ischemia were investigated. materials and methods stroke was induced by embolizing a preformed clot into the mca. rats were assigned to vehicle, a-tct (1 or 10 mg/kg), rgz and sham-operation. results compared to the control group, only rgz decreased infarct volume (p<0.05), neurological deficits (p<0.05) and sensory impairments (p<0.01) but low and high doses of a-tct did not show any significant neuroprotective effect. conclusion our data showed that a-tct was not neuroprotective at 3 hr after the embolic model of stroke. further studies should be undertaken to clarify the neuroprotective effects of a-tct after stroke.

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عنوان ژورنال:
iranian journal of basic medical sciences

جلد ۱۲، شماره ۱، صفحات ۹-۱۷

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