an investigation of the relationship between serum vitamin e status and coronary risk factors in dyslipidaemic patients

objective vitamin e is a major lipid-soluble antioxidant. it has been demonstrated that vitamin e supplementation has a beneficial effect against coronary heart disease (chd). this study to investigate the effects of coronary risk factors on serum vitamin e status in patients with dyslipidaemia. materials and methods this tertiary care hospital; case - control study was comprised 237 dyslipidaemic patients and 135 healthy individuals recruited from university and hospital employees. serum vitamin e concentration was measured using high performance liquid chromatography (hplc). results compared to the healthy individuals, the dyslipidaemic patients had higher serum vitamin e (p<0.001), but serum vitamin e / total cholesterol ratio did not differ between patients and healthy controls (p>0.05). serum vitamin e did not differ between subcategories of dyslipidaemic patients with and without coronary risk factors (p>0.05), but serum vitamin e / total cholesterol ratio was higher in patients with established coronary heart disease (p<0.01), hypertriglyceridaemia (p<0.05) and metabolic syndrome (p<0.05). in the patients there was not a strong association between serum vitamin e or serum vitamin e / total cholesterol ratio and coronary risk factors except for the serum cholesterol. conclusion serum vitamin e or vitamin e / total cholesterol ratio is not associated with the risk of coronary heart disease. therefore, higher serum vitamin e or vitamin e / total cholesterol ratio doesn’t seem to have a preventive role against coronary heart disease.