association of the cetp taqib polymorphism with coronary artery disease in type 2 diabetic patients

abstract      background and objective: diabetes mellitus is the most common risk factor for coronary artery disease (cad). cholesteryl ester transfer protein (cetp) taqib polymorphism is associated with changes in lipid profile and may be a risk factor for cad in patients with diabetes. this study aimed to evaluate the association of cetp taqib polymorphism with cad in patients with type 2 diabetes.      methods: in this case-control study, 292 diabetic patients were divided into two groups based on angiography reports (150 participants with normal angiogram as the control group and 142 participants with more than 50% stenosis of at least one coronary artery as the case group). the cetp taqib genotypes were determined by pcr-rflp analysis. fasting blood glucose was measured using glucose oxidase and lipid profile (triglycerides, total cholesterol, high density lipoprotein-cholesterol and low density lipoprotein-cholesterol) by an enzymatic method.        results: there was no significant difference in the frequency of genotypes and alleles between the case group and controls (the control group: b1b1, 17.3%; b1b2, 63.3%; and b2b2, 19.3%; the case group: b1b1, 18.3%; b1b2, 64.1%; and b2b2, 17.6%) (p=0.92). in the control group, heterozygous participants (genotype b1b2) had higher levels of cholesterol compared with other genotypes (b1b1 and b2b2). also, the patients with genotype b1b2 had significantly higher weight (p=0.013).        conclusion: there is no significant correlation between cetp taqib polymorphism and the increased risk of coronary artery disease in patients with type 2 diabetes.       keywords: cholesterol ester transfer protein, polymorphism, diabetes mellitus, type 2, coronary artery disease