the effect of vitamin e and selenium on cyclophosphamide detoxification in hepatic tissues of mature rats
نویسندگان
چکیده
introduction and objective: liver is an important body organ without which life is impossible. cyclophosphamide is an alkylating agent widely used as an anti-cancer (“antineoplastic” or “cytotoxic”) chemotherapy drug. the present study aimed to find a suitable antioxidant and examine the effect of vitamin e and selenium on reducing the side effects of cyclophosphamide on liver as a vital organ. materials and methods: in this experiment, 42 mature female rats were divided into 6 groups. the control group did not receive any drug or solvent. the first experimental group received 1 mg / kg-b.w sodium selenite as intraperitoneal injection. the second experimental group received 200 mg / kg-bw 200 vitamin e orally. the third experimental group received 5 mg / kg-bw cyclophosphamide as intraperitoneal injection. the fourth and fifth experimental groups respectively received 5 mg / kg-bw cyclophosphamide as intraperitoneal injection in a daily manner and 1 mg / kg-bw 1 sodium selenite as intraperitoneal injection and 200 mg / kg-bw 200 vitamin e orally for 21 days. the hepatic tissue slides were prepared and examined. results: the hepatic cells were normal in control group. no difference in hepatic tissue was observed in the first and second experimental groups. cellular necrosis was observed in the third experimental group. destruction of hepatocytes in hepatic cells was highly observed in the fourth and fifth experimental groups compared to the third experimental group. furthermore, congested blood sinusoids and lymphocyte infiltration was less observed in the fourth and fifth experimental groups compared to the third experimental group. conclusion: cyclophosphamide cause damage to hepatic tissues with different mechanisms such as production of reactive oxygen species. vitamin e and sodium selenite relatively reduce negative effects of cyclophosphamide.
منابع مشابه
The Effect of Vitamin E and Selenium on Cyclophosphamide Detoxification in Hepatic Tissues of Mature Rats
Introduction and Objective: liver is an important body organ without which life is impossible. Cyclophosphamide is an alkylating agent widely used as an anti-cancer (“antineoplastic” or “cytotoxic”) chemotherapy drug. The present study aimed to find a suitable antioxidant and examine the effect of vitamin E and selenium on reducing the side effects of cyclophosphamide on liver as a vit...
متن کاملThe Effect of Vitamin E and Selenium on Cyclophosphamide Detoxification in Hepatic Tissues of Mature Rats
Introduction and Objective: liver is an important body organ without which life is impossible. Cyclophosphamide is an alkylating agent widely used as an anti-cancer (“antineoplastic” or “cytotoxic”) chemotherapy drug. The present study aimed to find a suitable antioxidant and examine the effect of vitamin E and selenium on reducing the side effects of cyclophosphamide on liver as a vit...
متن کاملthe effect of aqueous extract of garlic on formalin-induced pain in male rats
چکیده اثر عصاره آبی سیر بر درد ناشی از آزمون فرمالین در موش صحرایی نر به کوشش نرگس اسکندری روزبهانی زمینه و هدف: گیاه سیر از خانواده لیلیاسه و گونهallium sativum بومی آسیای میانه بوده و از دوران ،باستان تاکنون به خواص درمانی متفاوت آن مثل: کاهندگی قندخون، کلسترول خون، فشار خون، اثرات مفیدآن بر دستگاه قلبی عروقی و بیماریهای انعقادی خون، اثرات آنتی اکسیداتیو، درمان بیماریهای تنفسی وگوارشی، ا...
15 صفحه اولthe effect of e-64 on the developmental competence of sheep cocs during in vitro maturation
in the present study, the effect of e-64 at different concentrations (0.5, 1, 5 and 10 µm) added to (1) the ivm medium on oocyte nuclear maturation and developmental competence of ovine oocytes, and (2) to the ivc medium on embryonic development of ovine embryos were investigated.
the effect of explicit teaching of metacognitive vocabulary learning strategies on recall and retention of idioms
چکیده ندارد.
15 صفحه اولthe washback effect of discretepoint vs. integrative tests on the retention of content in knowledge tests
در این پایان نامه تاثیر دو نوع تست جزیی نگر و کلی نگر بر به یادسپاری محتوا ارزیابی شده که نتایج نشان دهندهکارایی تستهای کلی نگر بیشتر از سایر آزمونها است
15 صفحه اولمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
international journal of advanced biological and biomedical researchناشر: casrp publishing company
ISSN 2383-2762
دوره 2
شماره 4 2014
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023