Fluorinated analogs of malachite green: synthesis and toxicity.

نویسندگان

  • George A Kraus
  • Insik Jeon
  • Marit Nilsen-Hamilton
  • Ahmed M Awad
  • Jayeeta Banerjee
  • Bahram Parvin
چکیده

A series of fluorinated analogs of malachite green (MG) have been synthesized and their toxicity to Saccharomyces cerevisiae and a human ovarian epithelial cell line examined. The toxicity profiles were found to be different for these two species. Two analogs, one with 2,4-difluoro substitution and the other with 2-fluoro substitution seem to be the most promising analogs because they showed the lowest toxicity to the human cells.

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عنوان ژورنال:
  • Molecules

دوره 13 4  شماره 

صفحات  -

تاریخ انتشار 2008