Animal Models for Hydrodynamic Gene Delivery
نویسندگان
چکیده
Hydrodynamic gene delivery (HGD) is an established method of the last decade where macromolecules, non-normally permeable to cell membrane, are delivered intracellular. The basic principle is that a large volume of solution, containing genes or oligonucleotides, RNA, proteins or other compounds, is infused rapidly in circulation to permit the entrance of these substances to parenchymal cells. Excellent review papers are published summarizing the principles, the applications and the progress that has been made in this field1-10 The aim of this chapter is to describe the basic principles of the hydrodynamic gene delivery, the surgical procedures in all animal models and the reflection of our scope for the future development.
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