The Mutation SN Leads to N-glycosylation and Increases the Cleavage of High Molecular Weight Kininogen In Rats Genetically Susceptible to Inflammation

Blood MS #2003-02-0661 The Mutation SN Leads to N-glycosylation and Increases the Cleavage of High Molecular Weight Kininogen In Rats Genetically Susceptible to Inflammation Irma Isordia-Salas, Robin A. Pixley , Hemant Parekh , Satya P. Kunapuli , Fengling Li, Anthony Stadnicki, Yingzhang Lin, R. Balfour Sartor , and Robert W. Colman. The Sol Sherry Thrombosis Research Center and 2 Department of Pathology and Laboratory Medicine Temple University School of Medicine, Philadelphia, PA USA 19140, USA Center for Gastrointestinal Biology and Disease University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA Running Title: A single mutation increases cleavage of HK by kallikrein. Scientific Heading: Hemostasis, Thrombosis and Vascular Biology Grants and Financial Support: This work was supported by grants of the NIH RO1 DK 43735, HL60683 and P30 DK 34987 as well as a research grant from the Crohn’s and Colitis Foundation of America. Correspondence and reprint request to: Robert W. Colman, M.D. The Sol Sherry Thrombosis Research Center Temple University School of Medicine 3400 North Broad Street Philadelphia, PA 19140 Phone (215) 707-4665 FAX(215) 707-2783 Email: [email protected]