The Metabolism of Histidine
نویسنده
چکیده
The mechanism of and possible cofactors involved in the straight deamination of histidine remain unknown. Neither pyridoxal phosphate, established as a cofactor in transamination of many amino acids, nor biotin, implicated in the straight deamination of aspart,ic acid, apparently plays a role in this reaction (1). Ichihara et al. (2) have reported low levels of histidase in the livers of rats which were fed goat,% milk (presumably low in folic acid) or diets which contained Aminopt,erin. However, conflicting reports (3, 4) have been published as t,o the effect of folic acid on the activation of partially purified preparations of liver histidase. If folic acid were to function in some coenzyme role in straight deamination reactions, additions to or revisions of present concepts (5) of the mode of action of derivatives of this vitamin would seem to be required. Thus, it was of interest to study furt,her the effects of dietary folic acid deficiency on levels of liver enzyme syst,ems involved in the metabolism of histidine.
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