Benfotiamine and Type 2 Diabetes Mellitus
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چکیده
The number of people with type 2 diabetes mellitus (T2DM) has been increasing worldwide [1]. The majority of patients with long-term course of diabetes mellitus (DM) (mainly T2DM) are diagnosed with cardiovascular diseases. Conditionally, there are two main forms of heart disease in case of DM: diabetic cardiomyopathy and ischemic heart disease (IHD). There is a metabolic stage (actual cardiomyopathy); metabolic-ischemic stage-IHD; myocardial infarction (MI); dystrophic coronary cardiosclerosis; cardiac autonomic neuropathy (CAN) [2]. Pathogenetic treatment includes: balanced diet and physical activity; reducing insulin resistance; optimization of glycaemic control; treatment of hyperlipidaemia; correction of metabolic abnormalities in myocardium; prevention and treatment of thrombosis; antioxidants, first of all α-lipoic acid (ALA); use of ω-3 polyunsaturated fatty acids; vasodilators; fat-soluble vitamin B1 (benfotiamine); treatment of concomitant diseases and syndromes (hypertension, heart failure and arrhythmias) and others [3,4]. The aim of this mini-review was to analyze the latest evidence about the effects of benfotiamine (BFT) (a lipid-soluble thiamine derivative with higher bioavailability than thiamine) on some metabolic and functional parameters in T2DM patients with diabetic angio-, neuropathies.
منابع مشابه
A Double-Blind, Randomized, Placebo-Controlled Clinical Trial on Benfotiamine Treatment in Patients With Diabetic Nephropathy
OBJECTIVE To investigate the effect of benfotiamine on urinary albumin excretion (UAE) and the tubular damage marker kidney injury molecule-1 (KIM-1) in patients with type 2 diabetes and nephropathy. RESEARCH DESIGN AND METHODS Patients with type 2 diabetes and UAE equivalent to 15-300 mg/24 h, despite ACE inhibitors (ACE-Is) or angiotensin receptor blockers (ARBs), were randomly assigned to ...
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متن کاملBenfotiamine and Type 2 Diabetes Mellitus
The number of people with type 2 diabetes mellitus (T2DM) has been increasing worldwide [1]. The majority of patients with long-term course of diabetes mellitus (DM) (mainly T2DM) are diagnosed with cardiovascular diseases. Conditionally, there are two main forms of heart disease in case of DM: diabetic cardiomyopathy and ischemic heart disease (IHD). There is a metabolic stage (actual cardiomy...
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