Confounding by Population Stratification A Guided Reading in Genetic Epidemiology Educational Objectives
نویسندگان
چکیده
Case-control association studies are a widely used study design in genetic epidemiology. Under this method allele and/or genotype frequencies at a genetic marker are compared between cases and controls. Association studies are thought to be well suited for identifying genetic variation underlying complex traits, such as diabetes, cancer and cardiovascular disease. However, this study design is susceptible to potential confounding by population stratification.
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