5-HT4R activation in hippocampal brain slices
نویسندگان
چکیده
5-HT4 receptor (5-HT4R) activation induces pro-cognitive effects. This might be related to stimulation of hippocampal acetylcholine (ACh) release, which has been shown for 5-HT4R agonists in in vivo models. We investigated the influence of the 5-HT4R agonists prucalopride and BIMU-8 on ACh release in rat hippocampal brain slices. In contrast to the report by Siniscalchi et al. [1], no facilitating effect of 5-HT4R agonists on electrically evoked ACh could be shown. The in our hands absence of an effect by 5HT4R agonists illustrates that the in vitro evaluation of 5-HT4R agonists on hippocampal ACh release is not a straightforward model to study the relationship between hippocampal 5-HT4Rs and hippocampal ACh release. 3-10 keywords or short phrases for cross-indexing ACh release; Hippocampal brain slices; prucalopride; BIMU-8
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