Effect of Chronic Treatment with None Steroidal Anti-Inflammatory Drug (Diclofenac) on Kidney Scinitgraphy

Our previous study investigated the effect of a single dose of NSAID diclofenac, which is the most commonly used to relieve kidney pain, on the renograms using radiopharmaceuticals. The objective of this study is to examine the effect of long-term use of diclofenac on renography. A baseline study (control) was done by injecting the rabbits Tc-DTPA and a renography was performed. Two days later an i.v. dose of diclofenac was given daily for 8 days. M Results: Diclofenac treatment shifted the renogram to the right compared to the control curves indicating that there was a delayed renal uptake of the tracer and clearance of radioactivity. The calculated average values of Tmax and T 1⁄2 for control and treated rabbits were (5.4±0.5 and 12.9±1.5 min) & (13.35±3 and 29.50±4 min) respectively, (n=12; *p<0.05). Diclofenac, prostaglandins synthesis inhibitor, delayed both the time to reach peak renal activity (Tmax) and the subsequent renal clearance time (T1⁄2), and tracer arrival in the bladder was delayed. These results prove that long-term use or a single dose of NSAID have similar effect on Renography. Therefore, we suggest not to use NSAIDs before doing renography to avoid misleading results.