Vertebrate hox gene regulation: clustering and/or colinearity?
نویسنده
چکیده
The relationship between the clustered organization of vertebrate Hox genes and their coordinate transcription in space and time is still lacking a convincing mechanistic explanation. Recent work on the regulatory interactions within Hox complexes suggests some reasons why these genes have remained clustered. Although these results do not address the puzzling issue of colinearity directly, they nevertheless add novel important input to the debate.
منابع مشابه
The Hox complex - an interview with Denis Duboule. Interviewed by Richardson, Michael K.
Denis Duboule is one of the most influential and highly-cited scientists in developmental biology. Born in Geneva in 1955, he holds dual Swiss and French nationality. His undergraduate studies in biology at the University of Geneva included research on mouse embryology. He later learned molecular techniques in the laboratory of Pierre Chambon, becoming a major player in characterising the newly...
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عنوان ژورنال:
- Current opinion in genetics & development
دوره 8 5 شماره
صفحات -
تاریخ انتشار 1998