Use of para-aminosalicylic acid in chronic pulmonary tuberculosis.
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چکیده
منابع مشابه
Mechanisms involved in the resistance of Mycobacterium tuberculosis to para-aminosalicylic acid.
That para-aminobenzoic acid antagonizes competitively the inhibitory effect of paraaminosalicylic acid on the growth of Mycobacterium tuberculosis is well known. In a previous communication (Hedgecock, 1956) it was reported that inhibition of M. tuberculosis (strain H37Rv) by para-aminosalicylic acid was reversed noncompetitively by methionine and biotin when the concentration of the inhibitor ...
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Courses of antituberculous chemotherapy are more prolonged than ever, and the problem of the unpleasant side effects of the administration of para-aminosalicylic acid (PAS) harasses both patient and physician for longer periods of time. Clinicians who manage tuberculosis are quite familiar with the difficulties entailed in keeping an appreciable number of their patients on an uninterrupted, pro...
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The development of resistant strains of tubercle organisms Is the main problem in using continuous antimicrobial therapy in the treatment of tuberculosis. Streptomycin and isonicotinic acid hydrazide have both been found to have a bactericidal action on tubercle organisms in the laboratory; the action of streptomycin varies directly with the concentration of the drug while the action of the iso...
متن کاملDeep Pelvic Retractor.
At present the administration of streptomycin intramuscularly concurrently with para-aminosalicylic acid by mouth is the standard method of anti-bacterial treatment in pulmonary tuberculosis. The investigations which have led to the general adoption of this combined treatment are outlined and current indications for its use briefly discussed. Though streptomycin has serious toxic effects and li...
متن کاملEthambutol compared to streptomycin in original treatment of advanced pulmonary tuberculosis.
In this randomized three year study of the primary treatment of 332 patients with cavitary or far advanced pulmonary tuberculosis, ethambutol (I Mitt was com pared to streptomycin (SM). One hundred eighty days of SM was compared to 180 days of EMB with each drug part of a three-drug regimen including isoniazid (INH) and para-aminosalicylic acid (PAS). A regimen of EMB-INH was compared to the th...
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ورودعنوان ژورنال:
- Diseases of the chest
دوره 16 1 شماره
صفحات -
تاریخ انتشار 1949