Antitumor activity of mycophenolic acid.

Carbamoyl mycophenolic acid ethylester, an oral antitumor agent.

Several derivatives of mycophenolic acid (MA) were tested for their antitumor activity against leukemia L-1210 when administered orally and carbamoyl mycophenolic acid ethylester (CMAE) was selected as the most active antitumor agent in these tests. An oral administration of CMAE also inhibited the growth of Ehrlich solid carcinoma, NF sarcoma, myeloma X-5563 and sarcoma 180 in mice. In compari...

Antiviral activity of mycophenolic acid. Studies on antiviral and antitumor antibiotics. IV.

Antitumor activity of derivatives of mycophenolic acid.

One hundred and eight derivatives of mycophenolic acid (MA) have been prepared by modifications at the phenolic hydroxyl and/or carboxyl sites. None of these compounds was as effective as MA in suppressing cell growth of L-518Y cell in vitro, whereas several compounds with changes at both the hydroxyl and carboxyl groups were more effective than MA against Ehrlich solid carcinoma and L-1210 leu...

Variation of hepatic malic enzyme capacity with hepatoma susceptibility in mice of different genotypes.

1791 Metabolic Effects of Cyclic 9-f3-D-Arabino furanosyladenine 3' , 5'-Monophosphate in L1210 Cells. Robert G. Hughes, Jr., and A. P. Kimball. 1795 Experimental Antitumor Activity and Pre clinical Toxicology of Mycophenolic Acid. Martin J. Sweeney, Koert Gerzon, Paul N. Harris, Richard E. Holmes, Gerald A . Poore, and Robert H. Williams. 1803 Metabolism and Biochemistry of Mycophenolic Acid. ...

Cytochrome C and Caspase-3/7 are Involved in Mycophenolic Acid-induced Apoptosis in Genetically Engineered PC12 Neuronal Cells Expressing the p53 Gene

Mycophenolic acid (MPA) is the active metabolite of mycophenolate mofetil. This study designed to investigate the mechanism of cytotoxicity of MPA on the genetically engineered PC12 Tet Off (PTO) neuronal cells with p53 gene. Alamar Blue (AB) reduction showed concentration-dependent cytotoxicity of MPA on PTO cells with IC50 value of 32.32 ± 4.61 mM. The reactive oxygen species (ROS) generation...