Liver Capsule: FXR agonists against liver disease
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چکیده
E P A T O L O G Y 2011;5303-1312. 3. Ingaki T , M oshetta A , ee Y K , P ng L, Z ao G , D ow es M , et l. R eglation of antcterial deense in he sm ll instine by he nulear ile acid reptor. P oc N tl A ad S ci U S A 2006;7:3920-3925. 4. N eens F , A ndeone P , M azella G , S trsser S I, B ow us C , Invrnizzi P , et l. A placecontrolled tial of obicholic acid in rim ry bliary chongitis. N E gl J M ed 2016;:631-643. R ecived July 2, 216; acep ed A ug st 3, 216. D O I 10.02/hep .2836 C op rig ht © 2016 he A uors. H EP A TO LO G Y p ub lihed b y W ley P eriod icals, Ic., on b ealf of he A m eican A ssiation or he S ud y of Lver D iseses. This is an op en acess aticle nd er he rm s of he C retive C om m ns A trib ution Linse, w hich p rm its use, d itrib ution nd ep od ution in ny m ed um , p rvid ed he rig ial w rk is p op rly cited . This w rk w as up p oted b y g rnts F 3008 nd F 3517 fom he A utrian S cnce F ound ation to M ). P otntial confl ct of inrest: D r. Truner cosults, is on he sp eaers’ b uau, nd reeived g rnts fom
منابع مشابه
Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis.
Farnesoid X receptor (FXR) is a bile acid-activated transcription factor that is a member of the nuclear hormone receptor superfamily. Fxr-null mice exhibit a phenotype similar to Byler disease, an inherited cholestatic liver disorder. In the liver, activation of FXR induces transcription of transporter genes involved in promoting bile acid clearance and represses genes involved in bile acid bi...
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The farnesoid X receptor (FXR) is expressed predominantly in tissues exposed to high levels of bile acids and controls bile acid and lipid homeostasis. FXR(-/-) mice develop hepatocellular carcinoma (HCC) and show an increased prevalence for intestinal malignancies, suggesting a role of FXR as a tumor suppressor in enterohepatic tissues. The N-myc downstream-regulated gene 2 (NDRG2) has been re...
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Non-alcoholic fatty liver disease (NAFLD) has become a predictive factor of death from many diseases. Farnesoid X receptor (FXR) is an ideal target for NAFLD drug development due to its crucial roles in lipid metabolism. The aim of this work is to examine the molecular mechanisms and functional roles of FXR modulation by avermectin analogues in regulating metabolic syndromes like NAFLD. We foun...
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