Introduction to Apoptosis Introduction to Apoptosis
نویسنده
چکیده
INDEX 1. The development of the term apoptosis....................................................... 2 2. The significance of apoptosis ....................................................................... 2 3. Morphological features of apoptosis............................................................ 4 4. Molecular mechanisms of apoptosis signalling pathways......................... 5 4.1 Various death signals activate common signalling ................................................5 4.2 Caspases are central initiators and executioners of apoptosis.................................7 4.3 Extrinsic apoptosis pathways of type I and type II .............................................. 10 4.4 Mitochondria as central regulators of intrinsic apoptosis pathways ...............................12
منابع مشابه
Morphine-induced apoptosis in PC12 cells: role of Bax and Bcl2
Introduction: It was reported that morphine could induce apoptosis in neurons. However, its specific mechanistic pathways remain elusive. The present study was undertaken to determine whether morphine could induce apoptosis in PC12 cells, a neuronal cell line, and the involvement of Bax and Bcl-2, as upstream factors of mitochondrial pathway. Methods: In an experimental study, the viabili...
متن کاملInduction of apoptosis in human tumor cell lines by platelets
Introduction: It has been reported that platelets can eradicate tumor cells in vitro, although the mechanism of this effect has not been determined. The effect of platelets on the induction of apoptosis in tumor cells is largely unknown. Materials and methods: To investigate this effect, two human hematologic cell lines, K562 and Daudi, were independently faced with unstimulated and thromb...
متن کاملCD44 expression changes and increased apoptosis in MCF-7 cell line of breast cancer in simulated microgravity condition
Introduction: Studies have shown that simulated microgravity (SMG) affects tumor cell proliferation and metastasis. However, the underlying mechanism and its molecular basis are still not well known. In recent years, due to the role of CD44 in breast cancer and its high expression in invasive basal tumors, it has been the subject of extensive research. There is a conflicting data on the role of...
متن کاملThe Effect of Different Concentrations of Smyrnium cordifolium (F: Apiaceae) Extract on Apoptosis and Proliferation of MCF-7
Introduction & objectives: Application of traditional medicine and identification of herbs to treat cancer are being on the rise. Little information is available on the anticancer effects of Smyrnium cordifolium bioss species. For this purpose, the present study investigated the cytotoxic and apoptotic effects of the alcoholic extract of S. cordifulium. Methods: After preparing the plant and ...
متن کاملProtective effect of curcumin and Curcuma longa extract on apoptosis of motor neurons in cultured spinal cord slices of adult mouse
Introduction: Since Curcuma longa extract and curcumin have been shown to be potent antioxidant agents, they were used in cultured adult mouse spinal cord slices to investigate whether they can inhibit apoptosis in motor neurons. Methods: Slices from the thoracic region of adult mice spinal cord were divided into four groups: 1. Freshlyprepared slices (time 0) 2. Control 3. Slices treated by cu...
متن کاملEffects of Hesperidin as a Radio-protector on Apoptosis in Rat Peripheral Blood Lymphocytes after Gamma Radiation
Introduction: Hesperidin (HES), as the most abundant flavonoid existing in the citrus, is widely used by human daily. The radio-protective effects of Hesperidin have been confirmed in various measurement systems. This study aimed to evaluate the effects of Hesperidin on the changes in the apoptosis level and expression of apoptotic genes target (bax, bcl-2 and ration of bax/bcl-2) in the periph...
متن کامل