Journal of International Academic Research for Multidisciplinary

نویسنده

  • MAJEED SALEH
چکیده

In 90 days neurotoxicity the number of degenerate mylinated nerve fiber were fewer than in acute neurotoxicity. The study consist of 4 groups as untreated control, low dose, intermediate dose and high dose. Control group was dosed orally daily for 90 days with corn oil, low dose group dosed with 1.25 mg/kg of TOCP, intermediate group dosed with 2.5mg/kg of TOCP and high dose group dosed with 5mg/kg in corn oil for 90 days. Electron microscopic changes were varying stages of degenerate myelin increase in severity with the dose and the character of degeneration myelin as spheroid body formation, lamellated body of degenerate myelin and clumps of degenerate myelin, exoplasm with vaying degrees of increase of neurofilament and presence of darck stanied degenerate lamelated mitochondria. furthermore evidence of degenerate of myelinated nerve and engulfment of degenerate myelin by Schwanns cells.

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تاریخ انتشار 2017