Binding between the Integrin!X"2 (CD11c/CD18) and Heparin*
نویسندگان
چکیده
Thomas Vorup-Jensen, Lianli Chi, Louise C. Gjelstrup, Uffe B. Jensen, Craig A. Jewett, Can Xie, Motomu Shimaoka**, Robert J. Linhardt, and Timothy A. Springer From the Immune Disease Institute (formerly CBR Institute for Biomedical Research), Departments of Pathology and **Anesthesia, Harvard Medical School, Boston, Massachusetts 02115, the Biophysical Immunology Laboratory, Institute of Medical Microbiology and Immunology, and the !Department of Human Genetics, University of Aarhus, DK-8000 Aarhus C, Denmark, and the Department of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York 12180
منابع مشابه
Regulated expression and function of CD11c/CD18 integrin on human B lymphocytes. Relation between attachment to fibrinogen and triggering of proliferation through CD11c/CD18
CD11c/CD18 (p150,95) is a beta 2 integrin expressed by myeloid, natural killer and certain lymphoid cells such as some cytotoxic T cell clones and B cell malignancies. We have studied the expression and function of CD11c on resting and activated B lymphocytes. Flow cytometry, immunoprecipitation, and mRNA analyses showed that cell activation with phorbol esters or with a variety of stimuli such...
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beta 2 integrin (CD11a,b,c/CD18)-mediated cell adhesion is required for many leukocyte functions. Under normal circumstances, the integrins are nonadhesive, and become adhesive for their cell surface ligands, the intercellular adhesion molecules (ICAMs), or soluble ligands such as fibrinogen and iC3b, when leukocytes are activated. Recently, we defined a peptide derived from ICAM-2, which speci...
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