The Chemistry of Vitamin E
نویسنده
چکیده
In a previous communication (1) some of us described the isolation from wheat germ oil of an alcohol, C&Hb002, having marked vitamin E activity, for which we proposed the name a-tocopherol. The substance itself was an oil, and was isolated in the form of the allophanate melting at 158-160’ from which it could be easily regenerated by alkaline hydrolysis. From it was also obtained a p-nitrophenylurethane, crystallizing in fine needles melting at 129-131”. The substance was believed to be homogeneous because adsorption of the allophanate on a column of calcium carbonate from benzene solution gave end-fractions of the same melting point, which on hydrolysis yielded alcohols of the same biological activity. Furthermore, a-tocopherol from the allophanate was converted to the p-nitrophenylurethane, which was recrystallized to constant melting point, and then reconverted t.o the allophanate which, after a few recrystallizations, melted at 158-160”. The extra step in purification effected no change in the biological activity or in the absorption spectrum of the a-tocopherol.
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