Microcirculatory Effects of Emulsified Fat Infusions.

• The effects of experimental and clinical hyperlipemia on microcirculation have been considered in discussions and hypotheses regarding the causation of fat embolism, the changes of blood lipids after trauma, and the pathophysiological responses to orally or parenterally administered fat emulsions. The mechanism by which fat embolism develops after traumata, especially fractures, has not been conclusively analyzed. While Adler and Peltiersuggested that local fat release from the damaged marrow directly to the circulation is the responsible mechanism, Bergentz in a review postulated that the composition of blood lipids is changed by trauma, leading to microcirculatory disturbances. These are manifested mainly by erythrocyte aggregation.