[Thyroid hormone resistance syndromes].
نویسنده
چکیده
Thyroid hormone resistance syndromes are a group of genetic conditions characterized by decreased tissue sensitivity to thyroid hormones. Three syndromes, in which resistance to hormone action is respectively due to mutations in the gene encoding for thyroid hormone receptor TRβ, impaired T4 and T3 transport, and impaired conversion of T4 to T3 mediated by deiodinases. An updated review of each of these forms of resistance is provided, and their pathogenetic mechanisms and clinical approaches are discussed.
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ورودعنوان ژورنال:
- Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion
دوره 58 4 شماره
صفحات -
تاریخ انتشار 2011