Effet of low-dose Aspirin on mortality of Acute myocardial Infarction

SUMMARY Between Aug. 1982 and March 1984, In a prospective, randomized trial approximately 24 hours after the onset of acute myocardial, infarction (MI), the influence of Low dose aspirin (120-150 mg/day, just during inhospital phase), on inhospital and post- hospital mortality rate was studied in 62 patients, and compared with control group. The two groups were comparable with regard to age, sex, Location of MI, Prior MI, congestive heart failure, arrhythmia (ventricular, premature beat and atrial fibrillation), right bundle branch block, bifasicular block and previous history of high blood pressure. In hospital mortality was markedly fewer in patients treated with aspirin (1.6 Percent, vs 19.4 percent, P<0.005) Patients who survived the hospital phse of acute Myocardial infarction, were followed for five years. No significant differences in fiveyear mortality rate were found between aspirin and control groups (38.7 percent VS 38.7 percent). We conclude that, in the acute phase of myocardial infarction, low dose aspirin is associated with a significant reduction of mortality and should be recieved in a longterm period after hospital discharge.