تغییرات شاخصهای کارکرد کلیوی در کارگران شاغل در پمپ بنزین ها با توجه به چند شکلی ژنتیکی آنزیمهای GSTM1 و GSTT1

The possible health effects of chronic exposure to petroleum products, in particular exposure to gasoline is an issue of public health concern. Filling station workers are at great risk of exposure to gasoline.           To determine the health effects of gasoline exposure on filling station workers, a cross-sectional study was conducted in Shiraz on 56 male gasoline workers and 56 age and sex matched control subjects with no occupational exposure to gasoline. Renal function test was done in the study population. To elucidate the role of hepatic detoxifying enzymes, the genotypes of glutathione S-transferases (GST) M1 and T1 were determined.    Data analysis was done by multiple regression and nonparametric Kruskal-Wallis test.           Results showed that all measurements were in normal range, although subclinical changes were detected in some indices. The present results showed that exposure to gasoline was associated with increased serum creatinine (t=3.33, P=0.001). No difference was detected for this finding in workers with different GST genotypes. Overall due to detection of subclinical changes in renal tests in gasoline station workers, exposure limitation and    administrating safety devices is recommended.           Also for monitoring health status of workers, doing baseline renal tests and repeating them in appropriate interval is suggested.