درباره اثر مدر اسید اتاکرینیک ETHACRYNIC ACID
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Hepatocellular damage with ethacrynic acid.
A man aged 25 with rheumatic heart disease (mitral stenosis and aortic stenosis with incompetence), subacute bacterial endocarditis, and gross congestive cardiac failure was admitted to the K.E.M. Hospital, Bombay, on 24 August 1966. He was given the appropriate antibiotic therapy, a low-salt diet, digitalis, and ethacrynic acid. In the first eight days the diuretic response was good and he los...
متن کاملHypotensive Effect of Ethacrynic Acid.
THE benzothiadiazine derivatives were the first diuretic compounds that could safely be administered over considerable periods of time and yet retain their effectiveness. In the course of the investigation of their diuretic properties in man it became apparent that they also possessed weak antihypertensive properties.' The mechanism of this action remains uncertain, and there is doubt as to whe...
متن کاملReversible Conjugation of Ethacrynic Acid with Glutathione
The reversibility of the conjugation reaction of the diuretic drug ethacrynic acid (EA), an a,~-unsaturated ketone, with glutathione and glutathione S-transferase PI-1 (GST PI-I) has been studied. When the glutathione conjugate of EA was incubated with a 5-fold molar excess of Nacetyi-L-cysteine or GST PI-I, a time-dependent transfer of EA to N-acetyI-L-cysteine or GST PI-1 was observed. With i...
متن کاملTransscleral diffusion of ethacrynic acid and sodium fluorescein
PURPOSE One of the current limitations in developing novel glaucoma drugs that target the trabecular meshwork (TM) is the induced corneal toxicity from eyedrop formulations. To avoid the corneal toxicity, an alternative approach would be to deliver TM drugs through the sclera. To this end, we quantified ex vivo diffusion coefficient of a potential TM drug, ethacrynic acid (ECA), and investigate...
متن کاملEthacrynic Acid: Effectiveness and Mode of Diuretic Action in Man.
ETHACRYNIC ACID is an unsaturated ketone derivative of phenoxyacetic acid* chemically different from other known diuretic agents.' Compounds of this general class have a significant ability to bind sulfhydryl groups in vitro. Ethacrynic acid was shown by Baer and associates2 to be highly effective as a diuretic in the dog, but not in the rat. A preliminary report from this laboratory indicated ...
متن کاملThe ototoxic effects of ethacrynic acid in man and animals.
A review of the literature was carried out to summarize the ototoxic effects of ethacrynic acid on man and animal. The effects of this drug on the electrolytes of the endolymphatic and perilymphatic systems, on the cochlear potentials and the auditory cortical-evoked responses, were reviewed. Histological animal studies determined by light and electron microscopy were described. Potentiation of...
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عنوان ژورنال
دوره 23 شماره None
صفحات 507- 510
تاریخ انتشار 1965-04
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