مقایسه اثر مهاری دو فرآورده دارویی گریپ میکسچر و کاراوی میکسچر بر اسپاسم ناشی از استیل کولین در روده موش صحرایی

In comparison of effects of various drugs with the same indications&nbsp;produced by different companies or comparing drugs manufactured in Iran&nbsp;with their foreign counterparts may result in producing drugs with higher&nbsp;qualities in our country. In this study the spasmolithic effect of two herbal&nbsp;drugs , gripe mixture and caraway mixture , that are prescribed as&nbsp;spasmolithic and carminative in infants were compared. &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; 2 cm of rat jejunum was placed in a organ bath containing tyrode&nbsp;solution (37 C&deg; , 100% O2) . The jejunum was contracted because of&nbsp;acetylcholine (1mml). when the muscle contraction reached the plateau&nbsp; the different volumes of drug were added to the organ bath. The inhibitory&nbsp;effect of drug indicated by physiograph , the intestine was washed two&nbsp;times. When the intestine reached the basal tonicity , the different volumes &nbsp;&nbsp; of second drug were tested. The results were compared using paired t.test&nbsp;. The results show that both drugs inhibit the spasm induced by &nbsp;&nbsp; acetylcholine in rat jejunum . This inhibitory effect was dose dependent. The&nbsp;caraway mixture showed a higher effect in comparison with gripe mixture&nbsp;(P<0.05). &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; The caraway mixture has a higher inhibitory effect on acetylcholine &nbsp;&nbsp; induced spasm in rat jejunum . It seems that it has the same effect on &nbsp;&nbsp; human.