A review on electrospun nanofibers for oral drug delivery
Nowadays, polymer nanofibers have gained attention due to remarkable characteristics such as high porosity and large surface area to volume ratio. Among their fabrication methods, electrospinning technique has been attracted as a simple and reproducible approach. It is a versatile, simple and cost-effective technique for the production of continuous nanofibers with acceptable characteristics such as high porosity, high surface area to volume ratio, high loading capacity and encapsulation efficiency, delivery of multiple drugs, and enhancement of drug solubility. Due to these properties electrospun nanofibers have been extensively used for different biomedical applications including wound dressing, tissue engineering, enzyme immobilization, artificial organs, and drug delivery. Different synthetic and natural polymers have been successfully electrospun into ultrafine fibers. Using electrospun nanofibers as vehicles for oral drug delivery has been investigated in different release manners- fast, biphasic or sustained release. This article presents a review on application of electrospinning technique in oral drug delivery.
Conventional transdermal drug delivery systems (TDDS) have been designed for drug delivery through the skin. These systems use the permeability property of stratum corneum, the outermost surface layer of the skin. Applying polymeric micro and nanofibers in drug delivery has recently attracted great attention and the electrospinning technique is the preferred method for polymeric micro-nanofiber...متن کامل
conventional transdermal drug delivery systems (tdds) have been designed for drug delivery through the skin. these systems use the permeability property of stratum corneum, the outermost surface layer of the skin. applying polymeric micro and nanofibers in drug delivery has recently attracted great attention and the electrospinning technique is the preferred method for polymeric micro-nanofiber...متن کامل
PURPOSE The objective of this study was to prepare a suitable form of nanofiber for indomethacin using polymers Eudragit RS100 (ERS) and Eudragit S100 (ES) and to evaluate the effect of some variables on the characteristics of resulted electrospunnanofibers. METHODS Electrospinning process was used for preparation of nanofibers. Different solutions of combinations of ERS, ES and indomethacin ...متن کامل
Design and performance investigation of electrospun PVA nanofibers containing core-shell nanostructures for anticancer drug delivery
Objective: The purpose of this work was design and performance investigation of a nanocarrier based on magnetic nanofibers containing core-shell nanostructuresfor anticancerdrug delivery of daunorubicin (DAN) by measuring their drug release at different pH values. Methods: Fe3O4 nanoparticles and [email protected] nanostructures were synthesized through coprecipitation and Stöber methodresp...متن کامل
A novel controlled release drug delivery system for multiple drugs based on electrospun nanofibers containing nanoparticles.
This study describes development of a novel controlled drug release system for multiple drugs, it consisted of Chitosan nanoparticles/PCL composite electrospun nanofibers with core-sheath structures. Two model agents' rhodamine B and naproxen were successfully loaded in the core and sheath region respectively. The behavior of these two agents demonstrated a good controlled release and temporali...متن کامل
Synthesis and cytotoxicity evaluation of electrospun PVA magnetic nanofibers containing doxorubicin as targeted nanocarrier for drug delivery
Objective(s): The purpose of this study was preparation and evaluation of PVA-Fe3O4 nanofibers as nanocarrier of doxorubicin (DOX) by measuring their drug release together with their in vitro cytotoxicity toward cancer cells at different pH values. Methods: Fe3O4 nanoparticles were synthesized by coprecipitation...متن کامل
دوره 4 شماره 4
صفحات 197- 207
تاریخ انتشار 2017-10-01
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