Association of hyperhomocysteinemia with coronary artery disease in southern Iran
Dear Editor, In response to the criticisms regarding the article entitled; “association of hyperhomocysteinemia with coronary artery disease in Southern Iran”, published in Iran J Med Sci,1 we still believe the methodology used in this study was a case control design as the cases where chosen on the basis of outcome (coronary artery disease) and the controls were individuals without the disease or outcome. In this study the individual affected by coronary artery disease were compared with a control group of unaffected individuals. The history of both cases and controls were analyzed to identify the characteristic and risk associated with hyperhomocystenemia present in the cases. Regarding the relative risk terminology we agree with the critics that perhaps the “estimate or approximate relative risk” would have been a better terminology to use in this case control study rather than relative risk.We also agree with the critics that cohort study would have been a better option but the estimate relative risk derived from the case control studies often agree with those obtained from the cohort studies.
Background: Differences in the prevalence and impact of hyperhomocytenemia on vascular disease between countries and races have been reported. Most studies have been undertaken in North American and European populations and the importance of plasma total homocysteine (tHcy) level as a risk factor for coronary artery disease in the Middle East particularly in Iran, however, is not known. Object...متن کامل
dear editor, in response to the criticisms regarding the article entitled; “association of hyperhomocysteinemia with coronary artery disease in southern iran”, published in iran j med sci, 1 we still believe the methodology used in this study was a case control design as the cases where chosen on the basis of outcome (coronary artery disease) and the controls were individuals without the dise...متن کامل
Association Study of rs1333040 and rs1004638 Polymorphisms in the 9p21 Locus with Coronary Artery Disease in Southwest of Iran
Background: Coronary artery disease (CAD) is a multifactorial and heterogenic disease. Recently, genome-wide association studies have reported that rs1333040 (C/T) and rs1004638 (A/T) single nucleotide polymorphisms (SNPs) in the 9p21 locus have very strong association with CAD. This study aimed to examine these associations in Southwest of Iran. Methods: Blood samples were collected from 200 C...متن کامل
CYP2C19 Genetic Polymorphism in the East of Iran: Its Association with the Severity and Pattern of Coronary Artery Disease
Introduction: Since there has been a dearth of research on the assessment of CYP2C19 polymorphism in the east of Iran (Khorasan provinces), this study aimed to detect, CYP2C19*2 and CYP2C19*3 allele frequencies among patients with coronary artery disease. The participants were selected among those referring to Emam Reza Hospital, Mashhad, Iran. Furthermore, the current research was motivated to...متن کامل
The Association of Glomerular Filtration Rate with Coronary Artery Disease in Type 2 Diabetic Patients
Objective: Chronic kidney disease (CKD) and diabetes mellitus can influence coronary artery disease (CAD) independently. The aim of this study was to evaluate the association of glomerular filtration rate (GFR) and CAD in type 2 diabetic patients (T2DM). Materials and Methods: This cross sectional study evaluated 3624 T2DM patients with clinical presentation of CAD whose documents were registe...متن کامل
دوره 30 شماره 1
تاریخ انتشار 2005-03-01
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