Association Study of rs3184504 C>T Polymorphism in Patients With Coronary Artery Disease
Cardiovascular disease has become the main factor of death and birth defects in the world and also in Iran. New clinical studies have shown that early diagnosis of patients with coronary artery disease (CAD) can contribute to effective prevention or therapeutic structures, which reduce mortality or the next chance of cardiovascular events, and increase the quality of life. Most studies on CAD disease and its genetic risk factors so far, have been done excluding the Iranian population. PubMed was used to search for all relevant studies published on or before 2013 and rs3184504 was selected for association study for CAD. A total of 200 subjects with 100 cases and 100 controls were ultimately included in the analysis. Blood samples were collected and after DNA extraction the DNA analysis was performed by TaqMan Probe Real Time PCR to evaluate the association between candidate variant with the disease and some blood biochemical factors. Our study demonstrated that there was not a direct association between rs3184504 C>T variant with risk of CAD in Iranian population, whereas, there is a significant association between this variant with increased blood LDL and diastolic blood pressure. Further molecular analysis and other disease association studies are necessary in the Iranian population.
cardiovascular disease has become the main factor of death and birth defects in the world and also in iran. new clinical studies have shown that early diagnosis of patients with coronary artery disease (cad) can contribute to effective prevention or therapeutic structures, which reduce mortality or the next chance of cardiovascular events, and increase the quality of life. most studies on cad d...متن کامل
Abstract Background and Objective: Diabetes mellitus is the most common risk factor for coronary artery disease (CAD). Cholesteryl ester transfer protein (CETP) TaqIB polymorphism is associated with changes in lipid profile and may be a risk factor for CAD in patients with diabetes. This study aimed to evaluate the association of CETP TaqIB polymorphism with CAD in...متن کامل
Background: Differences in the prevalence and impact of hyperhomocytenemia on vascular disease between countries and races have been reported. Most studies have been undertaken in North American and European populations and the importance of plasma total homocysteine (tHcy) level as a risk factor for coronary artery disease in the Middle East particularly in Iran, however, is not known. Object...متن کامل
Dear Editor, In response to the criticisms regarding the article entitled; “association of hyperhomocysteinemia with coronary artery disease in Southern Iran”, published in Iran J Med Sci,1 we still believe the methodology used in this study was a case control design as the cases where chosen on the basis of outcome (coronary artery disease) and the controls were individuals without the disease...متن کامل
دوره 3 شماره None
صفحات 157- 165
تاریخ انتشار 2014-06
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