CXCL10 Gene Expression in the Lung Tissue of Sulfur Mustard-Exposed Patients with Long-Term Pulmonary Complications
Aims: Mustard gas is an alkalizing substance that can lead to damage to DNA and intracellular enzymes. The aim of this study was to investigate the expression of CXCL10 in chemically-injured veterans’ lung tissue. Materials & Methods: This case-control study was done on 16 lung paraffin blocks of individuals exposed to mustard gas and 7 lungs paraffin blocks not-exposed people as control group and with similar chronic pulmonary disorders in 2014. Real-Time PCR technique was used to measureCXCL10 expression in lung tissue. To measure the relative expression of genes CT Delta method was used. Data were analyzed using SPSS 20 software and Mann-Whitney test. Findings: Mean Delta CT of veteran samples was 7.37±3.58 and control group was 5.81±3.29 and no significant difference was observed between 2 groups and between exposed and non-exposed subgroups (p>0.05). CXCL10 gene expression pattern was same in exposed and not-exposed group with similar pulmonary pathology. Conclusion: The level and pattern of CXCL10 expression is not different in lung tissue of two exposed and not-exposed with similar pulmonary pathology groups.
epidermal hydration and skin surface lipids in patients with long term complications of sulfur mustard poisoning
background: despite almost the three decades passed since the chemical attacks of iraqi’s army against the iranian troops, some veterans are still suffering from long-term complications of sulfur mustard (sm) poisoning, including certain skin complaints specially dryness, burning, and pruritus. we thus aimed to evaluate the skin’s water and lipid content in patients with a disability of >25% du...متن کامل
The Role of Oxidative Stress in Severity of Obstructive Pulmonary Complications in Sputum of Sulfur Mustard-Injured Patients
Background: Sulfur mustard (SM) is a strong bifunctional alkylating agent that causes delayed complications in organs such as lung. Oxidative stress plays a pivotal role in the pathogenesis and progression of many pulmonary diseases. The aim of this study was to investigate the oxidative stress in sputum of SM exposed patients with mild, moderate and severe pulmonary dysfunction and assessing t...متن کامل
Introduction: IFN-γ is one of the most important cytokines in the development of chronic inflammatory diseases such as asthma and COPD. The IFN-γ promoter methylation at CpG islands could be altered by various chemical and toxic substances which may have a role in the incidence of chronic pulmonary diseases and its severity. Thereby, the present study was aimed to evaluate the effect of sulfur ...متن کامل
Epidermal hydration and skin surface lipids in patients with long-term complications of sulfur mustard poisoning
BACKGROUND Despite almost the three decades passed since the chemical attacks of Iraqi's army against the Iranian troops, some veterans are still suffering from long-term complications of sulfur mustard (SM) poisoning, including certain skin complaints specially dryness, burning, and pruritus. We thus aimed to evaluate the skin's water and lipid content in patients with a disability of >25% due...متن کامل
Keywords: Sulfur mustard, Respiratory injury, health status, diseaseمتن کامل
lung exposure to sulfur mustard (sm) results in pulmonary complications, which is the main cause of long-term disability and morbidity. up to now, the precise mechanisms of sm-induced lung complications has not been identified. the aim of this study was to evaluate apoptosis in the lung tissue of sm-exposed individuals. the study was performed on archived lung paraffin-embedded tissue specimens...متن کامل
دوره 7 شماره 1
صفحات 35- 42
تاریخ انتشار 2015-02
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