Delayed combination therapy of local brain hypothermia and decompressive craniectomy on acute stroke outcome in rat
نویسندگان
چکیده مقاله:
Objective(s):Hypothermia and decompressive craniectomy (DC) have been shown to be neuroprotective. This study was designed to evaluate neuroprotective effects of delayed singular or combination of DC and local hypothermia on stroke. Materials and Methods: Cerebral ischemia was induced in 48 Wistar rats assigned to 4 groups: control, decompressive craniectomy (DC), local hypothermia (LH), combination of hypothermia and craniectomy (HC). Infarct size and BBB disruption were measured 48 hr after ischemia insult. Neurological deficits were assessed at 24 and 48 hr after stroke by using sticky tape test, hanging-wire test and Bederson’s scoring system. BBB disruption was measured by Evans blue dye leakage. Results: Although infarct size was significantly reduced in LH, DC and HC groups (P
منابع مشابه
delayed combination therapy of local brain hypothermia and decompressive craniectomy on acute stroke outcome in rat
objective(s):hypothermia and decompressive craniectomy (dc) have been shown to be neuroprotective. this study was designed to evaluate neuroprotective effects of delayed singular or combination of dc and local hypothermia on stroke. materials and methods: cerebral ischemia was induced in 48 wistar rats assigned to 4 groups: control, decompressive craniectomy (dc), local hypothermia (lh), combin...
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Hypothermia is considered a useful intervention for limiting pathophysiological changes after brain injury. Local hypothermia is a relatively safe and convenient intervention that circumvents many of the complications associated with systemic hypothermia. However, successful hypothermia treatment requires careful consideration of several factors including its practicality, feasibility, and asso...
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عنوان ژورنال
دوره 17 شماره 7
صفحات 476- 482
تاریخ انتشار 2014-07-01
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