Effect of Donepezil on Cognitive Disorders Due to the Selective Serotonin Reuptake Inhibitors in the Patients with Major Depressive Disorder
Introduction: Many factors cause cognitive impairment, including medication, such as selective serotonine reuptake inhibitor drugs use. On the other hand, many drugs are used in cognitive impairment therapy, including donepezil, which act by inhibiting the cholinesterase enzyme and increase brain acetylcholine. Methods: This study was a double-blind controlled randomized controlled clinical trial on the 73 numbers of 20-50 years-old patients treated with selective serotonine reuptake inhibitor drugs using Montreal Cognitive Assessment Test. They were randomly divided into two groups: placebo recipient and donepezil recipient. The Montreal Cognitive Test- reliability 92% and IC 83% - was performed two months after drug administration in both groups.The results were analyzed by Mann-Whitney, Chi-Square, T-test and has been reviewed by SPSS Inc., Chicago, IL; Version 16. Results: There was a significant difference in the Montreal Cognitive Test score before and after the intervention in the Donepezil group as the score increased. (Paired-T Test & P-Value < 0.0001). There was also a significant difference in Montreal Cognitive Test scores before and after the intervention in the placebo group (Paired-T Test & P-Value < 0.0001) as the score dropped. Conclusion: Cholinesterase inhibitors, such as donepezil, have had beneficial effects in improving cognitive impairment caused by selective serotonin reuptake inhibitor drugs compared to placebo. .
Effect of Selective Serotonin Reuptake Inhibitors and Immunomodulator on Cytokines Levels: An Alternative Therapy for Patients with Major Depressive Disorder
Major depressive disorder (MDD) is a psychiatric illness that presents as a deficit of serotonergic neurotransmission in the central nervous system. MDD patients also experience alterations in cortisol and cytokines levels. Treatment with selective serotonin reuptake inhibitors (SSRIs) is the first-line antidepressant regimen for MDD. The aim of this study was to determine the effect of a combi...متن کامل
Cognitive-Behavioral Therapy Versus Transcranial Direct Current Stimulation for Augmenting Selective Serotonin Reuptake Inhibitors in Obsessive-Compulsive Disorder Patients
Introduction: Obsessive-Compulsive Disorder (OCD) belongs to the categories of psychiatric disorders with the potential to turn into a chronic condition without receiving the necessary treatments. The main feature of OCD is the frequent or intense obsession and compulsion that might induce great pain and suffering in patients. Moreover, as one of the most prevalent abnormalities, depression usu...متن کامل
the effect of task cognitive complexity and time limit on the performance of the learners with different proficiency levels in second language writing skill
this study investigated the effects of manipulating the cognitive complexity of tasks along +/- few elements and the time limits on l2 learners writing performance. to conduct the study, 60 iranian efl learners with two levels of proficiency, low and high intermediate, were selected and assigned to three groups based on the time devoted to task completion. the participants performed both a simp...15 صفحه اول
the washback effect of discretepoint vs. integrative tests on the retention of content in knowledge tests
در این پایان نامه تاثیر دو نوع تست جزیی نگر و کلی نگر بر به یادسپاری محتوا ارزیابی شده که نتایج نشان دهندهکارایی تستهای کلی نگر بیشتر از سایر آزمونها است15 صفحه اول
A metaanalysis of clinical trials comparing moclobemide with selective serotonin reuptake inhibitors for the treatment of major depressive disorder.
OBJECTIVE To compare response rates among patients with major depressive disorder (MDD) treated with either moclobemide, an antidepressant thought to simultaneously enhance both noradrenergic and serotonergic neurotransmission, or selective serotonin reuptake inhibitors (SSRIs). METHODS Using a random-effects model, we combined 12 trials involving 1207 outpatients with MDD. RESULTS Patients...متن کامل
the effect of taftan pozzolan on the compressive strength of concrete in the environmental conditions of oman sea (chabahar port)
cement is an essential ingredient in the concrete buildings. for production of cement considerable amount of fossil fuel and electrical energy is consumed. on the other hand for generating one tone of portland cement, nearly one ton of carbon dioxide is released. it shows that 7 percent of the total released carbon dioxide in the world relates to the cement industry. considering ecological issu...
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دوره 27 شماره 10
صفحات 2017- 2026
تاریخ انتشار 2020-01
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