Effect of Ganciclovir on Pharmacokinetics of Mycophenolic Mofetil, in Kidney Transplant Patients

نویسندگان

  • Abdollah Bahrami Nephrology Ward, Department of Internal Medicine, Imam-Reza Hospital, MUMS, Mashhad, Iran
  • Amir hooshang Mohammadpoor Department of Pharmacodinamy & Toxicology, School of Pharmacy & Pharmaceutical Research Center, Mashhad University of Medical Sciences (MUMS), Mashhad, Iran
  • Fatmeh Nazemian Nephrology Ward, Department of Internal Medicine, Imam-Reza Hospital, MUMS, Mashhad, Iran
  • Marjan Kazemi Nephrology Ward, Department of Internal Medicine, Imam-Reza Hospital, MUMS, Mashhad, Iran
  • Masih Naghibi Nephrology Ward, Department of Internal Medicine, Imam-Reza Hospital, MUMS, Mashhad, Iran
  • Mohammad Hasanzade Khayyat Department of Medicinal Chemistry, School of Pharmacy & Pharmaceutical Research Center, MUMS, Mashhad,Iran
چکیده

ObjectiveMycophenolate mofetil (MMF) is commonly administered concomitantly with ganciclovir for managingtransplant recipients who infected with CMV. This study was conducted to evaluate the probable effects ofganciclovir on Mycophenolic acid (MPA) pharmacokinetic.Materials and MethodsTen kidney transplant recipients who full field inclusion and exclusion criterias enrolled in this study. Thefirst full profile blood sampling was taken during the combination therapy of gancyclovir and MMF. Thesecond sampling was taken one week after discontinuation of gancyclovir. Serum concentrations of MPAand its glucuronide metabolite (MPAG) were determined by high-performance liquid chromatography(HPLC) method. The pharmacokinetic parameters of MPA were measured, in two conditions, for eachpatient.ResultsThere was no significant difference between MPA clearance alone and in combination with ganciclovir(28.221.9 L/h vs 31.921.3 L/h, p=0.207) and also no significant difference was seen between the MPAArea Under the Curve (AUC) in two conditions (43.4816.27 μg/mlh vs 39.8020.18 μg/mlh, p=0.221).MPAG AUC was increased significantly when the drugs were administrated in combination (957.8675.2μg/mlh vs 134861095.1μg/mlh, p=0.036). Also ganciclovir induced entrohepatic recirculation of MPA intwo patients.ConclusionThe pharmacokinetic parameter of MPA was not affected by ganciclovir. But ganciclovir increased MPAGAUC and induced enterohepatic recirculation of MPA

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منابع مشابه

effect of ganciclovir on pharmacokinetics of mycophenolic mofetil, in kidney transplant patients

objectivemycophenolate mofetil (mmf) is commonly administered concomitantly with ganciclovir for managingtransplant recipients who infected with cmv. this study was conducted to evaluate the probable effects ofganciclovir on mycophenolic acid (mpa) pharmacokinetic.materials and methodsten kidney transplant recipients who full field inclusion and exclusion criterias enrolled in this study. thefi...

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عنوان ژورنال:

دوره 10  شماره 4

صفحات  233- 238

تاریخ انتشار 2008-10-01

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