Effect of Sulfur Mustard Toxicity on FLT3-ITD Gene Mutation in Sulfur Mustard Veterans

نویسندگان

  • Ali Asgharzadeh MSc of Hematology, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Mohyedin Barzegar Department of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Hossein Ayatollahi Anatomo Clinical Pathologist, Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Mahdi Balali-Mood PhD of Toxicology, Medical Toxicology Research Center, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Mohammad Rafiee Department of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Mohammad Reza Keramati Anatomo Clinical Pathologist, Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Mohammad-Hadi Sadeghian Anatomo Clinical Pathologist, Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Vahid Amiri Department of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
چکیده

Background: Sulfur mustard (SM) is a chemical blistering warfare that affects different organs especially hematopoietic system. Prevalence of acute myeloblastic and lymphoblastic leukemia is increased by sulfur mustard exposure. FLT3-ITD mutation can be effective on leukemogenesis. Therefore, the aim of this study was to verify the frequency of FLT3-ITD mutation in the patients who exposed to SM. Methods: This study was implemented on 42 people poisoned by SM during Iraq-Iran war about three decades ago and is now resident in Mashhad, Iran. The control group included 30 healthy males that are relatives of the patients with first-degree. After DNA extraction, PCR was performed for FLT3-ITD analysis. Results: By analysis of PCR products, no FLT3-ITD mutation was detected in the patient or control groups. There was no significant difference in hematological factors between the two groups. Conclusion: Other mechanisms can lead to leukemia in SM exposed persons. Elapsed time after exposure to sulfur mustard can be effective on leukemogenesis, then future more study may be beneficial for early diagnosis of leukemia in SM exposed veterans.

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عنوان ژورنال:

دوره 12  شماره None

صفحات  1- 4

تاریخ انتشار 2018-07

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