Evaluation of Application of Chitosan/nano Sodium Selenite Biodegradable Film on Full thickness Excisional Wound Healing in Rats
Objective- This study aimed at evaluation of histopathological findings of application of chitosan- nano selenium biodegradable film on full thickness excisional wound healing in rats. Design- Experimental Study Animals- Seventy-two male Wistar rats Procedures- Animals were randomized into six groups of 12 animals each. Group I: Animals with created wounds and no further treatment. Group II: Animals with wounds were dressed with chitosan film only. Group III: Animals with wounds were treated with sodium selenite. Group IV: Animals with wounds were treated with sodium selenium nanoparticles. Group V: Animals with wounds were dressed with chitosan/ sodium selenite film. Group VI: Animals with wounds were dressed with chitosan/nano sodium selenite film. Results- There were significant differences in comparisons of group VI and other groups, particularly in terms of cellular infiltration and neovascularization. During the study period, scores for neovascularization was significantly higher in group VI rats than other groups (P <0.05). Polymorphonuclear (PMN) and mononuclear (MNC) cell count and fibroblast cell proliferation in group VI were significantly higher than those of other experimental groups (P <0.05) Conclusion and Clinical Relevance- Chitosan/nano sodium selenite biodegradable film resulted in significant improvement in histopathological indices in full thickness wound healing. Thus, from this study it could be concluded that chitosan/nano sodium selenite biodegradable film have a reproducible wound healing potential and hereby justifies its use in practice.
Objective - The objective of the present study was to assess effect of Propolis in combination with chitosan biofilm on excisional wounds. Design- Experimental Study.Animals- Male healthy Wistar rats.Procedures- Sixty-four rats were randomized into four groups of 16 rats each. Group I: Animals with wounds treated with 0.9% saline solution. Group II: Animals with wounds were dr...متن کامل
Background and Objectives: Gastrotomy can be accompanied by serious postoperative complications. In this regard, the present study aimed to evaluate the effects of oral administration of silymarin on the histopathological and biomechanical characteristics of the gastric wall after experimental gastrotomy in rats. Methods: Full-thickness incision on the gastric wall and then suturing were con...متن کامل
Beneficial Effects of Nanocurcumin Loaded Chitosan Biofilm on Healing of Full Thickness Excisional Wounds in Diabetic Rats
Objective- In diabetes impaired wound healing and other tissue abnormalities are considered as major concerns. The novel therapeutic options for treatment of wound in diabetic patients are urgently needed. The aim of the present study was to assess beneficial effects of chitosan nanocurcumin biofilm on healing of full thickness excisional wounds in diabetic rats.D...متن کامل
effect of platelet rich plasma combined with chitosan biodegradable film on full-thickness wound healing in rat model
objective: to assess the effects of platelet rich plasma (prp) with chitosan biodegradable film on full thickness wound healing in rat. methods: this was an experimental study being performed in 2015 during a 4-month period. twenty-four male white wistar rats were divided into four groups of 12 rats each, randomly: control group (sham) with creation of wounds and no treatment, prp group with cr...متن کامل
OBJECTIVES Wound healing is a significant healthcare problem in today's medical practice. Despite extensive treatment modalities that are supposed to hasten the wound healing process, the outcomes of existing methods are far from optimal. One such agent that has been tried previously and found controversial in wound healing is phenytoin. In this study, the wound-healing efficacy of phenytoin wa...متن کامل
دوره 13 شماره 1
صفحات 14- 22
تاریخ انتشار 2018-07-18
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