Evaluation of JAK2 (V617F) Mutation in Iranian Veterans with Delayed Complications of Sulphur Mustard Poisoning
Background: Sulfur mustard was the most widely applied chemical warfare agent by the Iraqi army in Iran–Iraq war (1983-1988). Considering the role of sulfur mustard toxicity in hematopoietic neoplasms and also new role of JAK2 mutation in these neoplasms, we assessed this mutation and delayed hematologic complications in veterans exposed to sulfur mustard. Methods: This case control study was performed in Mashhad University of Medical Sciences, Mashhad, Iran in collaboration with Janbasan Foundation of Khorasan Razavi, Iran in 2012. The case group consists of 42 patients who exposed to sulfur mustard about 30 yr ago and the control group includes 30 healthy persons. For all subjects complete blood counts and ARMSpolymerase chain reaction for JAK2 (V617F) mutation was carried out. Data were analyzed by statistical software using independent sample t-testand Mann- Whitney U test. Results: JAK2 (V617F) mutation was detected, neither in the sulfur mustardveterans nor in the control group. Moreover no significant difference was detected in hematologic parameters between the two groups. Conclusion: Despite sulfur mustard can increase risk of tumor genesis especially hematologic neoplasms but this is probablyas result of other genetic mechanism apart from JAK2 mutation. Considering the health and importance of preventive measure for the sulfur mustard victims, we suggest other genetic aspects of tumor genesis to be assessed in these patients.
evaluation of jak2 (v617f) mutation in iranian veterans with delayed complications of sulphur mustard poisoning
background: sulfur mustard was the most widely applied chemical warfare agent by the iraqi army in iran–iraq war (1983-1988). considering the role of sulfur mustard toxicity in hematopoietic neoplasms and also new role of jak2 mutation in these neoplasms, we assessed this mutation and delayed hematologic complications in veterans exposed to sulfur mustard. methods: this case control study was p...متن کامل
Sulphur mustard is a chemical warfare agent, which was largely used during the World War One and in Iraq-Iran conflict. It may also be used as a chemical terrorism agent. Therefore, medical professions should have sufficient knowledge and be prepared for medical intervention of any such chemical attack.Sulphur mustard exerts direct toxic effects on the eyes, skin, and respiratory tract, with su...متن کامل
Delayed neurotoxic complications of chemical warfare agents (CWA), such as sulphur mustard (SM) and tabun, in human beings have not been reported in detail. We thus aimed to investigate possible neurotoxic complications of these agents in Iranian veterans 22-27 years after exposure. After co-ordination with the veteran foundation and obtaining the approval of the medical research ethics committ...متن کامل
sulphur mustard is a chemical warfare agent, which was largely used during the world war one and in iraq-iran conflict. it may also be used as a chemical terrorism agent. therefore, medical professions should have sufficient knowledge and be prepared for medical intervention of any such chemical attack. sulphur mustard exerts direct toxic effects on the eyes, skin, and respiratory tract, with s...متن کامل
Sulphur mustard (SM) is an alkylating agent that was first used as a chemical warfare agent during the First World War in 1917. SM is readily absorbed from the skin, respiratory and gastrointestinal tract and is distributed to several organs. SM may act rapidly and persistently upon DNA replicating mechanism of the individual cells during mitosis particularly in the hematopoietic system. O...متن کامل
A total of360 Iranian combatants who were exposed to mustard gas by the Iraqi forces in the war fronts were studied. Acute effects and gastrointestinal (GI) complications of sulfur mustard (S M) intoxication were studied separately in Iranian combatants admitted to Imam Reza Hospital from January 1984, to May 198X, In order to record the clinical and paraclinical findings, a special examina...متن کامل
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دوره 10 شماره None
صفحات 21- 24
تاریخ انتشار 2016-06
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