Gold-gold sulfide nanoshell as a novel intensifier for anti-tumor effects of radiofrequency fields


  • Ameneh Sazgarnia Medical Physics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  • Habibollah Esmaily Department of Biostatistics, Faculty of Health Sciences, Mashhad University of Medical Sciences, Mashhad, Iran
  • Hamid Reza Sadeghi Medical Physics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  • Hossein Eshghi 5 Department of Chemistry, School of Sciences, Ferdowsi University of Mashhad, Mashhad, Iran
  • Mohammad Hossein Bahreyni-Toosi Medical Physics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  • Naser Tayebi Meybodi 3 Department of Pathology, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
  • Samaneh Soudmand 1 Medical Physics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده مقاله:

Objective(s):Several studies have been carried out to investigate the effect of various nanoparticles exposed to radiofrequency (RF) waves on cancerous tissues. In this study, a colon carcinoma tumor model was irradiated by RF in the presence of gold-gold sulfide (GGS) nanoshells. Materials and Methods: Synthesis and characterization of GGS nanoshells were initially performed. CT26 cells were subcutaneously injected into the flank of BALB/c mice to create the colon carcinoma tumor models. Then the tumors were subjected to different treatments. Treatment factors included intratumoral injection of GGS and RF radiation. Different groups were considered as control with no treatment, receiving GGS, RF irradiated and simultaneous administration of GGS and RF. Efficacy of the treatments was evaluated by daily monitoring of tumor volume and recording the relative changes in it, the time needed for a 5-fold increase in the volume of tumor (T5) and utilizing pathologic studies to determine the lost volume of the tumors. Results: In comparison with control group, tumor growth was not markedly inhibited in the groups receiving only GGS or RF, while in the group receiving GGS and RF, tumor growth was effectively inhibited compared with the other groups. In addition, the lost volume of the tumor and T5 was markedly higher in groups receiving GGS and RF compared with other groups. Conclusion: This study showed that RF radiation can markedly reduce the tumor growth in presence of GGS. Hence, it can be predicted that GGS nanoshells convert sub-lethal effects of noninvasive RF fields into lethal damages

برای دانلود باید عضویت طلایی داشته باشید

برای دسترسی به متن کامل این مقاله و 31 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

A systematic review of gold nanoparticles as novel cancer therapeutics

Objective(s):The current systematic study has reviewed the therapeutic potential of gold nanoparticles as nano radiosensitizers for cancer radiation therapy.   Materials and Methods: This study was done to review nano radiosensitizers. PubMed, Ovid Medline, Science Direct, SCOPUS, ISI web of knowledge, Springer databases were searched from 2000 to September 2013 to identify appropriate studies....

متن کامل


The orthogonal array design has been used to determine the optimum conditions for gold recovery from Zarshuran refractory gold sulfide ore (Iran) by direct cyanidation and roasting-cyanidation. The Taguchi method was used as the experimental design to determine the optimum conditions of dissolution behavior of gold with cyanidation and roasting-cyanidation from Zarshuran refractory gold ore . T...

متن کامل

Optimized gold nanoshell ensembles for biomedical applications

: We theoretically study the properties of the optimal size distribution in the ensemble of hollow gold nanoshells (HGNs) that exhibits the best performance at in vivo biomedical applications. For the first time, to the best of our knowledge, we analyze the dependence of the optimal geometric means of the nanoshells' thicknesses and core radii on the excitation wavelength and the type of human ...

متن کامل

Antibody-conjugated gold-gold sulfide nanoparticles as multifunctional agents for imaging and therapy of breast cancer

The goal of this study was to develop near-infrared (NIR) resonant gold-gold sulfide nanoparticles (GGS-NPs) as dual contrast and therapeutic agents for cancer management via multiphoton microscopy followed by higher intensity photoablation. We demonstrate that GGS-NPs exposed to a pulsed, NIR laser exhibit two-photon induced photoluminescence that can be utilized to visualize cancerous cells i...

متن کامل


In this paper, gold leaching of a refractory sulfide concentrate by chloride–hypochlorite solution was investigated and effects of stirring speed, temperature and particle size on the leaching rate were reported. Experimental data for leaching rate of gold were analyzed with the shrinking–core model. Results were consistent with chemical reaction control mechanism in the first 1 h of leachin...

متن کامل

ذخیره در منابع من

ذخیره در منابع من قبلا به منابع من ذحیره شده

{@ msg_add @}

  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال

دوره 17  شماره 7

صفحات  516- 521

تاریخ انتشار 2014-07-01

با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.

میزبانی شده توسط پلتفرم ابری

copyright © 2015-2023