Preparation and evaluation of vitamin A nanosuspension as a novel ocular drug delivery
Objective(s): The aim of this study was to prepare a nanosuspension formulation as a new vehicle for the improvement of the ocular delivery of vitamin A. Material and Methods: Formulations were designed based on full factorial design. A high pressure homogenization technique was used to produce nanosuspensions. Fifteen formulations were prepared by the use of different combinations of surfactants Tween 80, benzalkonium chloride and Pluronic and evaluated for pH, particle size, entrapment efficiency, differential scanning calorimetry (DSC), stability and drug release. Also, Draize test was used to evaluate the irritation of rabbit eye by formulations. Results: All formulations showed a small mean size that is well suited for ocular application. Also it was observed that the particle size decreased with increase in the amount of surfactant. Drug entrapment increased with increasing amount of surfactant. It was shown that initial and final drug release can be controlled by the ratio and the total amount of surfactants, respectively. Conclusion: It was concluded that the use of Tween 80 and Pluronic in the formualtions with a proper ratio does not show eye irritation and could be useful to achieve a suitable nanosuspension of vitamin A as a novel ocular delivery system.
objective(s): the aim of this study was to prepare a nanosuspension formulation as a new vehicle for the improvement of the ocular delivery of vitamin a. material and methods: formulations were designed based on full factorial design. a high pressure homogenization technique was used to produce nanosuspensions. fifteen formulations were prepared by the use of different combinations of surfa...متن کامل
Preparation and evaluation of PCL-PEG-PCL micelles as potential nanocarriers for ocular delivery of dexamethasone
Objective(s): Micelles have been studied as nanoparticulate drug delivery systems for improving the topical ocular delivery of hydrophobic drugs. The objective of this study was to develop and characterize dexamethasone-loaded polycaprolactone-polyethylene glycol-polycaprolactone (PCL-PEG-PCL) micelles to improve patient compliance and enhance the ocular bioavailability of poorly water-soluble ...متن کامل
Preparation and in vitro evaluation of a novel chitosan-based hydrogel for injectable delivery of enrofloxacin
BACKGROUND: The development of injectable sustained-release products are of great interest to veterinary pharmaceuticals and animal health business. Recently, great attention has been paid to in situ gel-forming chitosan/beta-glycerophosphate (chitosan/β-GP) solutions due to their good biodegradability and thermosensitivity. OBJECTIVES: The general aim of this study was to prepare a novel in si...متن کامل
Cancer is a fatal disease and relatively widespread in the world; Breast cancer is the most prevalent cancer among women. Hydroxyurea (HU) is a chemotherapy drug for the cure of cancer different types in patients, for example breast cancer, but has several defects, for to remove these problems in this study a nanoliposome (NL) suspension for Hydroxyurea (HU) delivery in breast cancer cell thera...متن کامل
to discuss my point, i have collected quite a number of articles, anthologies, and books about "wuthering heights" applying various ideas and theories to this fantastic story. hence, i have come to believe that gadamer and jauss are rightful when they claim that "the individaul human mind is the center and origin of all meaning," 3 that reading literature is a reader-oriented activity, that it ...15 صفحه اول
Development and evaluation of bio-nanoparticles as novel drug carriers for the delivery of Donepezil
The purpose of the present study was to formulate and evaluate donepezil loaded bio-nanoparticles for effective treatment of Alzheimer’s disease. For the preparation of bio-nanoparticles biomaterial was isolated from fruits of Carica papaya by an economic method. The biomaterial recovered from the concentrate was subjected for various physicochemical properties like color, solubility, ...متن کامل
دوره 2 شماره 4
صفحات 283- 290
تاریخ انتشار 2015-10-01
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