Preventive effect of omega-3 fatty acids on ethinyl estradiolinduced hepatosteatosis in female wistar rat

نویسندگان

  • Ali Shahriari Department of Basic Sciences, Faculty of Veterinary Medicine Shahid Chamran University, Ahwaz, Iran
  • Marjan Chahardahcherik Department of Basic Sciences, Faculty of Veterinary Medicine Shahid Chamran University, Ahwaz, Iran
  • Peyman Asadian Department of Clinical Sciences, Faculty of Veterinary Medicine, Lorestan University, Khoramabad, Iran
  • Saleh Esmaeilzadeh Department of Pathobiology, Faculty of Veterinary Medicine, Shahid Chamran University, Ahwaz. Iran.
چکیده مقاله:

BACKGROUND: Hepatic steatosis due to estrogen therapyincreases the activity of inflammatory markers, particularly theactivity of TNFα which in turn induces more lipogenesis.Omega-3 fatty acids are among the negative regulators of hepaticlipogenesis. OBJECTIVES: In this research, the preventive effectof omega-3 fatty acids on estrogen-induced steatosis in rats wasevaluated. METHODS:2 mg/kg. BW/SC of 17α-ethiny-lestrasdiolwere injected into 25 female wistar rats in 5 equal groups(excluding the control group) over 10 consecutive days.Simultaneously, 3 of estradiol-treated groups were orally given250, 500, and 1000 mg/kg. BW omega-3 fatty acids, respectively.At the end of the experiment, plasma ALT, AST, and TNFαlevel were determined. Histopathological changes in the liverwere also identified by the evaluation of samples stained withH&E and Oil Red O. RESULTS: The histological findingsrevealed hepatic microvesicular steatosis and fat deposit inethinylestradiol and, to a lesser extent, in the 250 mg/kg BWomega-3 fatty acids groups. The plasma levels of AST, ALT, andTNFα significantly increased in the ethinylestradiol groupcompared to the control (p

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preventive effect of omega-3 fatty acids on ethinyl estradiolinduced hepatosteatosis in female wistar rat

background: hepatic steatosis due to estrogen therapyincreases the activity of inflammatory markers, particularly theactivity of tnfα which in turn induces more lipogenesis.omega-3 fatty acids are among the negative regulators of hepaticlipogenesis. objectives: in this research, the preventive effectof omega-3 fatty acids on estrogen-induced steatosis in rats wasevaluated. methods:2 mg/kg. bw/s...

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عنوان ژورنال

دوره 7  شماره 2

صفحات  129- 134

تاریخ انتشار 2013-07-01

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