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Protective effects of vitamin D on ischemia-reperfusion injury of the ovary in a rat model

نویسندگان

  • Mehmet Sipahi Department of Obstetrics and Gynecology, Giresun University, Giresun, Turkey
  • Ozlem Keskin Department of Cardiovascular Surgery, Giresun University, Giresun, Turkey
  • Selcuk Takir Department of Pharmacology, Giresun University, Giresun, Turkey
  • Vehbi Tokgoz Department of Obstetrics and Gynecology, Giresun University, Giresun, Turkey

چکیده

Objective(s): The aim of the present study is to investigate probable acute effects of vitamin D on ischemia-reperfusion injury in the rat ovary.Materials and Methods: A group of 30 Wistar albino rats was divided into five groups of 6 each. Group 1:  underwent laparotomy only and the ovaries were removed. Group 2:  3-hr ischemia followed by excision of the ovaries. Group 3:  3-hr ischemia and 3-hr reperfusion and the ovaries were removed. Group 4:  vitamin D was administered 30 min prior to the 3-hr of ischemia and the ovaries were excised at the end of ischemia period. Group 5:  vitamin D was administered 30 min prior to the 3-hr of ischemia and 3-hr reperfusion then the ovaries were removed at the end of reperfusion. The ovaries excised in each group also underwent biochemical and histopathologic analysis. MDA (malondialdehyde), SOD (superoxide dismutase), NO (nitric oxide), TAS (total antioxidant score), TOS (total oxidant score) were analyzed as biochemical parameters.Results: There were no significant differences between groups in TAS, TOS, or OSI (P>0.05). MDA levels were lower in the vitamin D treatment groups especially in group 5, significantly (P

جستجوی کلمه کلیدی

Ischemia
Ovary
Rats
Reperfusion
Torsion
Vitamin D

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