The association of serum omentin-1 levels with biochemical parameters in patients with nonalcoholic fatty liver disease

نویسندگان

  • Kolivand Saloki, Neda MSc, Department of Biotechnology, Medical Islamic Azad University, Tehran, Iran
  • Mohammadi, Mahnaz Assistant Professor, Department of Biology, Islamshahr Branch, Islamic Azad University, Islamshahr, Iran
  • Nagi, Tahereh Associate professor, Department of Biology, Medical Azad University Tehran, Iran
  • Nejdadali, Masoumeh Assistant Professor, Department of Biology, Islamshahr Branch, Islamic Azad University, Islamshahr, Iran
چکیده

Background: The incidence of non-alcoholic fatty liver disease (NAFLD) is increasing due to the growing epidemics of obesity. Omentin-1 is an anti-inflammatory adipokine produced preferentially by visceral adipose tissue. The aim of this study was to determine omentin-1 serum levels and its relationship with body mass index, fasting blood sugar and lipid profile. Materials and methods: This case-control study was performed on 70 patients with non-alcoholic fatty liver disease and 70 participants as controls. Plasma levels of omentin 1 were measured by ELISA kit and other variables were determined by standard methods. Data were analyzed using SPSS version 20 software. Results: Patients with non-alcoholic fatty liver presented significantly higher omentin levels compared to the controls (p<0.05). NAFLD patients had significantly higher levels of body mass index (BMI) and triglycerides, compared to healthy group (p-value<0.05). An inverse correlation was observed between omentin1with BMI, triglyceride, and LDL-C (p<0.05), but were positively associated with HDL‑C levels (p<0.05). We did find correlation between omentin‑1 with FBS in patients with non-alcoholic fatty liver (p<0.05). Conclusion: The findings showed that omentin-1 serum levels were significantly different in patients with NAFLD when compared to controls. Omentin levels are correlated with BMI, LDL-C, and HDL-C.

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عنوان ژورنال:

دوره 31  شماره None

صفحات  121- 127

تاریخ انتشار 2021-03

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