The effects of Petroselinum crispum extract on milk production parameters in female rats

Background and Aim: Use of medicinal plants is one of the methods to increase breast milk. Petroselinum crispum is a multipurpose herb in traditional medicine which contains essential amino acids, vitamins and numerous nutrients. This study aimed to determine the effects of Petroselinum crispum extract on milk production parameters in female rats. Material and Methods: In this experimental study, 32 Wistar female rats were randomly assigned to 4 groups; group1, control group (normal saline) and groups 2 to 4 (experimental groups). The experimental groups received various doses of  Petroselinum crispum (100, 150, 200 mg/kg/day intraperitoneally) for 21 days. Petroselinum crispum extract was prepared. Prolactin hormone measurements were carried out based on RIA prolactin radio immune assay method. Using morphometrical techniques, prolactin receptor (PRLR) mRNA expression level and histological evaluation of mammary gland tissue were investigated. Data were analyzed by one way ANOVA test. Results: Petroselinum crispum administration increased significantly all the parameters in experimental groups compared to those in the control group (P<0.0001). Conclusion: Petroselinum crispum extract had positive effects on the milk production parameters in mammary glands.