In positron emission tomography (PET), photon scattering inside the body causes significant blurring and quantification error in the reconstructed images. To solve this problem we have developed Monte Carlo (MC) based 3D PET reconstruction algorithms implemented on the Graphics Processing Unit (GPU). Our implementation takes multiple Compton scattering into account without any significant addit...

BACKGROUND Despite the early theoretical prediction of the 0+-0+ transition of 90Zr, 90Y-PET underwent only recently a growing interest for the development of imaging radioembolization of liver tumors. The aim of this work was to determine the minimum detectable activity (MDA) of 90Y by PET imaging and the impact of time-of-flight (TOF) reconstruction on detectability and quantitative accuracy ...

PET is a medical imaging modality with proven clinical value for disease diagnosis and treatment monitoring. The integration of PET and CT on modern scanners provides a synergy of the two imaging modalities. Through different mathematical algorithms, PET data can be reconstructed into the spatial distribution of the injected radiotracer. With dynamic imaging, kinetic parameters of specific biol...

In the context of improving detector performance time-of-flight positron emission tomography (TOF-PET), combination charge induction readout and prompt Cherenkov photon production in semiconductor materials can lead to an outstanding energy, timing, spatial resolution. Energy resolutions as good 1.2% at 662 keV 5% 122 are reported for pixel thallium bromide (TlBr) detectors. The high refractive...

Positron emission tomography (PET) is the imaging modality most extensively tested for treatment monitoring in particle therapy. Optimal use of PET in proton therapy requires in situ acquisition of the relatively strong (15)O signal due to its relatively short half-life (~2 min) and high oxygen content in biological tissues, enabling shorter scans that are less sensitive to biological washout. ...

The development of PET/MRI multimodality, requiring magnetic field immunity the photodetectors associated with an increased demand for time-of-flight capabilities a strong impact on effective PET sensitivity and image quality, has pushed medical imaging community to progressively replace photomultipliers, traditionally used in scanners, by solid-state photodetectors, avalanche diodes (APD) sili...

In quantitative PET measurements, the analysis of radiometabolites in plasma is essential for determining the exact arterial input function. Diphenyl sulfide compounds are promising PET and SPECT radioligands for in vivo quantification of the serotonin transporter (SERT) and it is therefore important to investigate their radiometabolism. We have chosen to explore the radiometabolic profile of [...

Abstract Background The goal of this work was to determine the quantitative accuracy and optimal reconstruction parameters for 124 I-PET imaging in presence therapeutic levels 131 I. In effort, images were acquired on a GE D710 PET/CT scanner using NEMA IEC phantom with spheres containing I increasing amounts activity background. At each level, two scans acquired, one centered field view (FOV) ...

Scintillation detector development is an active field of research, especially for its application to the medical imaging and in particular positron emission tomography (PET). Effective sensitivity signal-to-noise ratio PET are greatly enhanced when improving timing capabilities: availability provide time-of-flight (TOF) information. However, physical barriers related characteristics available o...

UNLABELLED Phantom studies have shown improved lesion detection performance with time-of-flight (TOF) PET. In this study, we evaluate the benefit of fully 3-dimensional, TOF PET in clinical whole-body oncology using human observers to localize and detect lesions in realistic patient anatomic backgrounds. Our hypothesis is that with TOF imaging we achieve improved lesion detection and localizati...